c-Fos peak in the history & alternative markers of neuronal activation

history of c-Fos as a marker of neuronal activation?
In the scientific literature, c-Fos was for the first time referred to as a marker of neuronal activation in:

1. Dragunow, M. & Faull, R. (1989). The use of c-fos as a metabolic marker in neuronal pathway tracing. Journal of Neurosci Methods, 29(3), 261-265. (paid)

2. Hoffman, G.E., Smith, M.S. & Verbalis, J.G. (1993). c-Fos and Related Immediate Early Gene Products as Markers of Activity in Neuroendocrine Systems. Frontiers in Neuroendocrinology, 14(3), 173-213.

at least as far as I could find in a brief literature search.

alternative markers of neuronal activation?

1. c-Jun
2. pERK
3. NGFI-B
= nerve growth factor IB
- ''the expression of NGFI-B after both routes of administration is indicative of cellular activation within the pPVN in parallel with secretion of ACTH.'' (Ogilvie et al., 1998)

It seems that selecting the best marker of neuronal activation depends on the neuronal population and the response to a particular stimulus studied.