My notes are based on a very old paper by Angelson & Betz (1997). I am not sure how much relevance it still has today. So keep that in mind.
Membrane capacitance
- capacitance of a membrane can be used to measure exocytosis/endocytosis, vesicular release and neurotransmitter release
- because as vesicles fuse with the membrane, its area and volume increase and it is able to 'store' more charge (explained here)
- however, this can be done well only with vesicles larger than 50 nm in diameter so apparently not that many...
- also, for this technique whole-cell clamp is less useful than perforated-cell clamp and than on-cell clamp
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